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KMID : 0390020120220040383
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Pediatric Allergy and Respiratory Disease
2012 Volume.22 No. 4 p.383 ~ p.389
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Increased Nasal Interleukin-33 in the Infants with Acute Respiratory Syncytial Virus Bronchiolitis
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Yang Seung-Ho
Chu Mi-Ae
Park Hye-Jin
Lee Kye-Hyang
Kim Woo-Taek
Chung Hai-Lee
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Abstract
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Purpose : Interleukin (IL)-33, a member of the IL-1 cytokine family, is considered to be important for innate-type mucosal immunity of the lung and also has been suggested to induce Th2-type immune responses. We aimed to investigate if IL-33 is involved in airway inflammation due to respiratory syncytial virus (RSV) infection in young children. Methods : Thirty-eight infants (≤24 months of age) admitted with their first episode of RSV bronchiolitis were enrolled in the study. Atopy was defined by having at least 1 allergen-specific immunoglobulin E (IgE), positive result to skin prick test, or high serum IgE levels. The patients were assessed to have severe symptoms when they had ≥2 of the following clinical findings: hypoxemia (＜92% oxygen saturation), rapid breathing (and/or lower chest wall indrawing), and ＞7 days of hospital stay. The levels of IL-33 and the IL-33 receptor (sST2) were measured using enzyme-linked immunosorbent assay in nasal secretion samples collected from the patients on admission and compared with 20 age-matched controls. We also investigated the levels of IL-33 and sST2 in relation to the atopic status and symptom severity of the patients. Results : Nasal IL-33 levels in the patients with acute RSV bronchiolitis were significantly increased (P＜0.05), but sST2 showed no difference compared to the controls. Neither IL-33 nor sST2 showed significant difference in relation to the atopic status or severity of symptoms. Conclusion : Our study showed significantly increased IL-33 in the nasal secretions of the young infants admitted with acute RSV bronchiolitis and suggests that IL-33 is involved in the pathogenesis of RSV-induced airway inflammation. [Pediatr Allergy Respir Dis(Korea) 2012;22:383-389]
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KEYWORD
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Interleukin-33, Iinterleukin-33 receptor, Respiratory syncytial virus, Bronchiolitis, Infant
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